Tag Archives: approach

To the Editor: Dr Sandkühler raises several relevant and interesting points regarding our review on activity-dependent central sensitization and synaptic plasticity, and we are happy to clarify our approach to, and understanding of, synaptic plasticity in the dorsal horn, particularly the relationship between central sensitization and long-term potentiation (LTP). The definition of LTP needs to be addressed, we believe, in the context of the type of preparation (in vivo or in vitro), nature of the neurons (cerebellum, neocortex, hippocampus, dorsal horn), the synaptic changes that occur (homo- or heterosynaptic, pre- or postsynaptic), duration of changes (short term or persistent), molecular mechanisms (signal transduction pathways engaged, transcription independent or dependent), and th…