Authors: Peters CM, Hayashida KI, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by 5-HT3 receptor antagonists in rats following spinal nerve ligation (SNL) but not sham operation
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