Cannador® (IKF-Berlin) is a cannabis extract administered in oral capsules, with differing figures as to THC:CBD ratios (reviewed in (Russo and Guy 2006)), generally approximately 2:1. Two pharmacokinetic studies on possibly related material have been reported (Nadulski et al 2005a; Nadulski et al 2005b). In a Phase III RCT employing Cannador in spasticity in multiple sclerosis (MS) (CAMS) (Zajicek et al 2003) (Table 1), no improvement was noted in the Ashworth Scale, but benefit was observed in spasm-associated pain on subjective measures. Both Marinol and Cannador produced reductions in pain scores in long-term follow-up (Zajicek et al 2005). Cannador was assayed in postherpetic neuralgia in 65 subjects with no observed benefit (Ernst et al 2005) (Table 1), and in 30 post-operative pain subjects (CANPOP) without opiates, with slight benefits, but prominent psychoactive sequelae (Holdcroft et al 2006) (Table 1).

No restrictions and our always-free shipping mean for unparalleled access to some of the world’s best in organic CBD’s. In addition, we are proud to say that we are quite knowledgeable in the CBD field and CBD applications as opposed to many out there, just trying to sell a product. If you need help deciding which CBD line is best for your intended application, we are always happy to explain the options to your fullest understanding.
Stage III Vulvar Cancer is visiting my body. I am taking CBD oil from the dispensary in Massachusetts. I put a rice grain size rubbed inside my mouth under my tongue. It is so terrible tasting, especially now with Chemo and Radiation, my stomach is ok, but I am getting almost nausea when putting the CBD Oil on my gums. Can I take it rectally or vaginally? Have you ever heard of this? Is it still just as effective as taken orally. I am only doing this because of my condition. It does help me sleep and I am more relaxed. I just wish I did not have to taste or smell it.
Speaking of dosage, in most clinical trials, you’ll see CBD dosing ranges from 10-800 mg of CBD per day (although to treat schizophrenia, I’ve seen doses as high as 1,300mg). But as with everything from whey protein to creatine to magnesium, everyone is different and you’ll likely need to experiment with a dosage range that works for you. The CBD capsules I personally use contain 10mg in one capsule, but based on the absorption (an important variable which you’re going to learn about next), I need to use far less CBD, about 1/10 the amount, compared to other CBD tinctures, extracts and capsules I’ve tried.
Full Extract Cannabis Oil (FECO) is also known as Rick Simpson Oil. Which has THC. Therefore makes you high. It's powerful stuff. Many people get knocked out by it, yet it's effective. Depends on what you are looking to do. Nature CBD does not have THC, so there is no high. Great for during the day or work. Active compounds in Nature CBD are CBD, Curcumin, Ashwagandha, Lemon Balm, Magnesium. FECO is just THC extracted oil.
Chronic pain is persistent and difficult to manage. For those looking for long-term relief, a CBD oil capsule may be your best bet. Unlike sublingual or inhaled CBD, oral capsules are active for up to six hours. However, it’s important to keep in mind that oral CBD takes longer to kick in, which means that some consumers may also want to supplement with a sublingual or inhaled CBD while waiting for the capsule to take effect.
My dad was diagnosed with a cancer, ( before i learnt of Rick Simpsons oil / RSO ) the hospital said to do chemotherapy and radiotherapy.. she did.. and went through a lot.. but no cure, after a while the doctors said the cancer was spreading and we could look for alternatives.. i searched the internet and found out about the oil.. asked alot of questions.. watched the videos etc.. we made the oil our selves but it couldn’t just work out we were doing more harm than good and the cancer was still there spreading, i searched more on the internet i found a testimony on how a lady got the oil via an email, i immediately copied the email: phoenixtearsoil5@gmail.com, i wrote to this very email and in an hour later i got a reply back asking me some few questions, and enlightened me on how to get the oil in the next 48hours, i placed my order and in the next 48hours the medication oil got to us. immediately my dad started using the oil, it been two months now, since my dad has been using the medication oil and his cancerous problems are gone this very fact was clarified by the doctor.
In general, the majority of people end up using higher-strength products for pain than they would for things like anxiety, stress, or depression. The majority of today’s best CBD oil manufacturers offer tinctures in three different “potencies,” usually in 100, 300, or 600 mg options. Many people start on a middle ground with a 300 mg option, and work your way up from there, but it is extremely important to consult with the brand you are purchasing from before consumption.
Pharmacists have since moved to metric measurements, with a drop being rounded to exactly 0.05 mL (50 μL, that is, 20 drops per milliliter) - https://en.wikipedia.org/wiki/Drop_(unit)1oz is 30 mL1000mg/30mL = 33.3 mg/mL CBD concentration20 drops * .05 mL/drop = 1mL10 drops * .05 mL/drop = .5mLyou take 33.3 mg in the morning and 16.65mg at nightI might suggest taking 50mg in the morning: 50mg / 33.3 mg/mL = 1.50 mL 30 dropstry it for a couple days and see how it helps
Using a process called “hybrid-nanoengineering” it is actually possible to get a highly bioavailable and absorbable form of CBD. The way that hybrid-nanoengineering works is that the cannabinoids and terpenoids are extracted from the hemp plant, combined with an Ayurvedic herbal blend and then processed into nanoparticle size. Nanoparticles (1/100 the width of a human hair) are easier for your body to absorb and transport to where they are needed within your body. This means that a hybrid-nanoengineered CBD is over 10x more bioavailable in the body than any other oil based CBD, CBD tincture or CBD capsule, and that just 10mg of a nanoparticle CBD is comparable to 100mg of standard CBD.
It's the Wild West out there. Without any federal regulatory body checking labels, consumers have very little way of knowing what they're buying when they purchase CBD oil. Bonn-Miller co-authored a study that found that 26 percent of CBD products on the market contained less CBD than their label claimed. So the amount you need for an effective dose could vary drastically, not just from product to product, but from bottle to bottle of the same product.
I have osteoarthritis, had a hip replaced, need the other one and both knees done. Started taking CBD oil 3 weeks ago and am pain free for the first time in 30 years. I no longer take anti inflamitories or pain pills. This stuff is a miracle! I have sinced recommended it to two friends with hip problems ans they are experiencing markedly less pain or no pain at all. Its a bit of experimentation to find the right dose, I take 4 drops under my tounge morning and night 500 mg. Works like a charm. Im active again, no stiffness no limping. Amazing!!!
Back pain can be extremely debilitating, and it’s understandable if you want to steer clear of pharmaceutical painkillers in favor of something a little more natural. That’s what makes this Green Label Raw CBD Oil from Herbal Renewals so special. Available in three sizes, it’s a potent concentrate that gets to work in around fifteen minutes, and it can last for up to twelve hours, bringing real relief to back aches.
Oral dronabinol (THC) is marketed in synthetic form as Marinol® (Solvay Pharmaceuticals) in various countries, and was approved in the USA for nausea associated with chemotherapy in 1985, and in 1992 for appetite stimulation in HIV/AIDS. Oral dronabinol’s expense, variability of action, and attendant intoxication and dysphoria have limited its adoption by clinicians (Calhoun et al 1998). Two open label studies in France of oral dronabinol for chronic neuropathic pain in 7 subjects (Clermont-Gnamien et al 2002) and 8 subjects (Attal et al 2004), respectively, failed to show significant benefit on pain or other parameters, and showed adverse event frequently requiring discontinuation with doses averaging 15–16.6 mg THC. Dronabinol did demonstrate positive results in a clinical trial of multiple sclerosis pain in two measures (Svendsen et al 2004), but negative results in post-operative pain (Buggy et al 2003) (Table 1). Another uncontrolled case report in three subjects noted relief of intractable pruritus associated with cholestatic jaundice employing oral dronabinol (Neff et al 2002). Some authors have noted patient preference for whole cannabis preparations over oral THC (Joy et al 1999), and the contribution of other components beyond THC to therapeutic benefits (McPartland and Russo 2001). Inhaled THC leads to peak plasma concentration within 3–10 minutes, followed by a rapid fall while levels of intoxication are still rising, and with systemic bioavailability of 10%–35% (Grotenhermen 2004). THC absorption orally is slow and erratic with peak serum levels in 45–120 minutes or longer. Systemic bioavailability is also quite low due to rapid hepatic metabolism on first pass to 11-hydroxy-THC. A rectal suppository of THC-hemisuccinate is under investigation (Broom et al 2001), as are transdermal delivery techniques (Challapalli and Stinchcomb 2002). The terminal half-life of THC is quite prolonged due to storage in body lipids (Grotenhermen 2004).
Francesca Fusco, MD, a dermatologist based in New York City, recently told Health that CBD oil is a rich source of fatty acids and other skin-healthy nutrients, and that it may improve hydration and minimize moisture loss. A few studies have also suggested that CBD oil may inhibit the growth of acne, although this hypothesis has only been tested in laboratory cell cultures—not in actual humans.

For those looking for something different, topical cannabidiol products are plentiful. There are lotions, gels, creams, pastes, lip balms, scrubs, salves, butters, oils, and transdermal patches. Topical CBD can be applied directly to the skin to relieve pain or reduce inflammation. Most topical products don’t enter the bloodstream, but patches are an exception.


Among the company’s many offerings is Real Scientific Hemp Oil, which it sells through its subsidiary HempMedsPx, also based in Poway. On its web site, HempMedsPx describes how its hemp “is grown in northern European microclimates, without the use of any pesticides, herbicides or chemical fertilizers.” The company promises that it “continuously scrutinizes and improves the processes to meet all regulations and exceeds quality standards.”

Thankfully, gone are the times when doctors were prescribing traditional painkillers and anti-inflammatories like candies. Now, with a greater level of awareness in terms of the complexity of chronic issues – such as pain, for example – we know that there is no magic pill to solve the issue and we need to defeat the core of the problem in order to get back on track with our lives.
Anti-inflammatory: Another cause of chronic pain is inflammation in the muscles and tissues. Over time, an overabundance of inflammation can cause damage to those tissues. Many people rely on prescription pain medications to dull those pains, but long-term usage of those medications can have negative effects on the kidney, stomach and liver. Hemp CBD oil is known for its natural anti-inflammatory properties without having any of those same harsh side effects.
Even though most manufacturers claim that CBD does not have any side effects, research says otherwise. Sure, most people can tolerate the impact of CBD just fine, but a small portion of the population have been noted to experience not-so-adverse side effects. According to Cannabis and Cannabinoid Research, the most common results are tiredness, change in weight, diarrhea, fatigue.
Hello. I have stage 4 thyroid, secondary lymphoma..And many other health issues.I use 50mg of cbd vapor oil. 5 drops with each use. Total equals 250mg, about hits per dose, three times a day. I'm also on subsys, which is fentanyl. Idk about anyone but myself, but it's helped me with pain, with sleep, and in general my moods. So I dint have anything negative to say. I just hope that with time, proper diet, low dose chemo, and some other herbal usage, that I can shirk some of the cancer eating at my body... Thanks and good luck to you all.
What a wonderful article! Unfortunately not all CBD is created equal! You definitely want to do your research! I suffer from a long list of ailments including chronic pain, anxiety, arthritis and depression. Long story short, my prescriptions simply didn’t work. I stumbled upon CBD by a friend. I did my research about the company and they checked out perfectly! The hemp is organically grown and harvested in the US. The products are created by the CEO of the company in his ISO certified lab and triple tested by a third party lab for purity and potency. They currently use the CO2 extraction method. Big things are on the horizon! This company is still in prelaunch. The flavors are AMAZING! I ditched my meds and began my CBD journey on June 28, 2018 and the products have changed my life and I am forever grateful. I decided to partner with this company and I would LOVE to talk with you more about the company and our products, maybe even do a review of them?! Thanks for the well written article! Xoxo
sharon wiese, If your 1000 mg bottle of CBD is 30 ml size, then there are about 1.3 mg CBD per drop. (25-30 drops per ml). Taking 6 drops per day, you are only getting 8 mg CBD per day. That is probably not enough to see results. I take a 30 mg gelcap per day as a maintenance dose. My friend was on 3400 mg gabapentin per day for nerve pain associated with shingles. She was able to ween off the gbp, but is using 150 mg of CBD per day. You shouldn’t start that high. Just keep increasing until you see results. Hope this helps.

MEDICAL DISCLAIMER: NO information on this site should be used to diagnose, treat, prevent or cure any disease or condition. By reading this website, you acknowledge that you are responsible for your own health decisions. Do not take anything from any website, including this one, and try it without proper research and medical supervision. Any statements or claims about the possible health benefits conferred by any foods or supplements have not been evaluated by the Food & Drug Administration (FDA) and are not intended to diagnose, treat, prevent or cure any disease.
If we were to pick one CBD seller that has changed the quality standards for cannabidiol-based products, it’s hands down Diamond CBD. The company gets its hemp from Scandinavia, where organic hemp plants are cultivated in fertile soil. Each plant is hand-selected before the harvest and processing. But the best part about DiamondCBD is that it offers literally every CBD product you could ever think of.
I have been on high amounts of opioids for 17 years( 640mg er oxycontin daily and 360 mg of oxycodone for breakthru pain daily. I’m 57 and do regularly physical therapy 4 times a week. Had vertrbra fractures, herniated discs, multiple surgeries and procedures. Could not walk for about 6 months back then in 1993, when injuries took place. When Insurance stopped paying for meds(2015/16), I took myself off these meds against medical advice. Was not going to pay this kind of money and hurt my family financially. I did accomplish getting off these and I thought I was going to die. But now I have been off 18 months. I do miss the pain relief from these meds, but not the side effects. Thank you for your very informative site. Will give some of these products a try. Thanks again for your review. I live in West Virginia. They passed medical marijuana, but dispeneries won’t open until June/July of 2019. In the meantime will try the CBD oil without the thc. Thanks again for your thorough info. Slbtrb79

As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
Cannabidiol (CBD), a non-psychoactive segment of the marijuana plant, has created huge enthusiasm among researchers and physicians.  CBD Oil applies its remedial effect on an atomic level is as yet being sorted out. Cannabidiol is a pleiotropic sedate in that it produces numerous impacts through various atomic pathways. CBD Oil acts through different receptor-free channels and by official with various non-cannabinoid receptors and particle channels.
But it’s not just CBD that can lend a helping hand. “Chronic pain is a symptom of rheumatoid arthritis, and when it comes to chronic pain, we have 9,000 patient years of data showing that THC [the active ingredient in cannabis] effectively treats it,” says Jahan Marcu, PhD, the Chief Scientific Officer for Americans for Safe Access, an organization devoted to the legalization of cannabis for therapeutic use. “Cannabinoids stop the transmission of pain and decrease inflammation, and that’s very important for people with joint issues.” On a basic level, THC is anti-inflammatory and analgesic (it kills pain), and it’s also known to reduce the anxiety and depression that goes with diseases (especially ailments that are cause a loss of mobility like rheumatoid arthritis). Have you ever read about how smoking weed can cause seizure patients to relax? Based on similar physiological principles, people with chronic pain and stiff joints may find that their body naturally loosens when using marijuana.

Instead, CBD acts as an agonist on an entirely different receptor called the 5-HT1A receptor, and this is how CBD actually works as an antidepressant with anti-anxiety and neuroprotective effects. It also serves as what is called an “allosteric modulator” of your opioid receptors, which is how it works to remove pain and reduce the effects of chronic inflammation. Other positive medical effects of CBD (there’s over 60 of them, if you care to read up on them here) are due to increased intracellular calcium release and agonism of another receptor called the PPAR-γ receptor.


Hi I've had rsd over 25 years now and in stage 3 I take cbd I'mor nong 6 weeks now and it's helped tons w my depression,sleep,constipation as well as energy. I take 2 drops under tounge every morning and Rick spson oil 3 xs day.It's bern beyond life changing for me look into the rs oil w the cbd. It works.. I still take 1 opiad a day have taken 2 a day only 3 times in almost 2 months when I was in bad flare ..

I am currently going through red skin syndrome/topical steroid withdrawal. The only cure as of now is time(6 months to 3 years) and waiting out horrible eczema-like flares. My main issue is burning/tingling skin that is almost constant. Steroids close off blood vessels and when you stop them they 'wake' up causing this nerve discomfort/pain. I've been smoking medical cannabis for the duration of my recovery(1.5 years) and It's done wonders except that the flare is around my mouth and I'm afraid the smoking is causing more issues.. as well as helping. I need to step up my game and take a different approach. I am wondering how to go about using cbd but I don't know where to start and was wondering if you could help. Thank you


There are a few other drawbacks to studies on CBD. First off, many involve rats rather than humans (including one that focuses on arthritis-related ache relief). Also, the science that does involve people doesn’t often include a large test group, Craft says. Finally, as Craft notes along with a review of CBD studies, there’s not much research out there about the long-term effects of cannabis-based meds.
Supercritical CO2 extraction. Subcritical/Supercritical CO2 oil extraction has several advantages over other extraction mediums, such as alcohol and hydrocarbons: CO2 is nontoxic and is Generally Regarded As Safe (GRAS) by the FDA for use in food products. Our bodies produce it when we breathe, and it is commonly used in carbonated beverages. With CO2 as a solvent for oil extraction, no toxins, heavy metals or hydrocarbon materials come in contact with the extracted oils. CO2 is “solvent free”. Other extraction solvents, such as hydrocarbon based propellants like propane and butane, hexane and pentane, or ethanol/alcohol mixtures require additional distillation or purging beyond the extraction process to separate the solvent from the extracted oil. CO2 has a very low boiling temperature and wants to be a gas a room temperature, thus it naturally separates from the extracted oil the same way a soda goes “flat”. The spent plant material is also free of residual solvents so it can be re-used as well. CO2 is non-flammable. Flammable solvents must be processed in a NEMA Class 1, Division 1, 2 or 3 (explosion proof) environment. CO2 is not flammable and does not require costly explosion proof facilities. CO2 is “cold” – Botanical oil extractions can be done at temperatures that are native to the botanical material, minimizing thermal degradation of the plant material and the extracted oil. CO2 is “tunable” – the solvency power of CO2 can be adjusted simply by increasing or decreasing pressures and/or temperatures. The ability of the CO2 to selectively extract affords the ability to create unique extractions that have varying levels of desirable oils and waxes (see below). Less desirable plant constituents, like chlorophyl, can also be “de-selected”. CO2 is inexpensive. CO2 is readily available and widely used throughout several industries. In addition, Apeks’ production CO2 oil extraction systems recirculate and subsequently recover 95% of the CO2 used in each extraction. CO2 is environmentally friendly. Industrial CO2 for extractions comes from byproducts – primarily hydrogen and ammonia manufacturing and fermentation for ethanol. CO2 used for extractions does not contribute to the overall atmospheric CO2 levels.

Anything that can be made of plastic can also be made from hemp, which can reduce exposure to phytoestrogens and other chemicals in plastic and other synthetic compounds. Hemp plant fibers are long and tough, and can be woven into a soft cloth that wears well and has fewer of the herbicides and pesticides associated with other modern cloths like cotton. Even copies of the Declaration of Independence used to be written on hemp paper, since it doesn’t yellow with age like other papers do.


Trying to believe that if we let her hit ‘rock bottom’ she would finally quit drinking. All that happened was that she became really ill and had to be taken to hospital. She isn’t the type of alcoholic who can carry on some kind of life. When she drinks, that is all she does. She stays in her flat and drinks and smokes all night and all day until she physicality cannot cope. Then she has a few days off it, then it all starts again.
When Brandon Krenzler’s daughter Mykayla was diagnosed with a form of childhood leukemia in 2012 at the age of seven, he began researching medical marijuana products that might ease her symptoms and blogging about the results. The next year, he received some samples of Real Scientific Hemp Oil, which he administered to Mykayla. But the oil made her sick.
I have tried NatureCBD and believe in the product. I particularly noticed alleviation in joint pain and reduction in stress – although stress reduction may have been supported by pain reduction. However, since I live in Canada and it is expensive to ship, I have been using CBD from a licensed medical marijuana facility. The effect is not as powerful as from NatureCBD. I had not really considered the bioavailability issue; perhaps that is the reason for the weaker effect. Or possibly it could be the other herbs added, or the synergistic effect. In any case, I am going to bite the bullet (at least my visa card will) and go back to NatureCBD.
THC, an intoxicating and illegal substance, is responsible for causing marijuana users to get “high.” Unlike THC, CBD is non-psychoactive because it does not act on the same pathways as THC. Thus, it is impossible to get “high” by smoking or ingesting CBD or CBD oil extracted from industrial hemp plants, as they only have minuscule traces of THC (<0.3%).
Sativex® (GW Pharmaceuticals) is an oromucosal whole cannabis-based spray combining a CB1 partial agonist (THC) with a cannabinoid system modulator (CBD), minor cannabinoids and terpenoids plus ethanol and propylene glycol excipients and peppermint flavoring (McPartland and Russo 2001; Russo and Guy 2006). It was approved by Health Canada in June 2005 for prescription for central neuropathic pain in multiple sclerosis, and in August 2007, it was additionally approved for treatment of cancer pain unresponsive to optimized opioid therapy. Sativex is a highly standardized pharmaceutical product derived from two Cannabis sativa chemovars following Good Agricultural Practice (GAP) (de Meijer 2004), yielding Tetranabinex® (predominantly-THC extract) and Nabidiolex® (predominantly-CBD extract) in a 1:1 ratio. Each 100 μL pump-action oromucosal Sativex spray actuation provides 2.7 mg of THC and 2.5 mg of CBD. Pharmacokinetic data are available, and indicate plasma half lives of 85 minutes for THC, 130 minutes for 11-hydroxy-THC and 100 minutes for CBD (Guy and Robson 2003). Sativex effects commence in 15–40 minutes, an interval that permits symptomatic dose titration. A very favorable adverse event profile has been observed in over 2500 patient years of exposure in over 2000 experimental subjects. Patients most often ascertain an individual stable dosage within 7–10 days that provides therapeutic relief without unwanted psychotropic effects (often in the range of 8–10 sprays per day). In all RCTs, Sativex was adjunctively added to optimal drug regimens in subjects with intractable symptoms, those often termed “untreatable.” Sativex is also available by named patient prescription in the UK and the Catalonia region of Spain. An Investigational New Drug (IND) application to study Sativex in advanced clinical trials in the USA was approved by the FDA in January 2006 in patients with intractable cancer pain.

In August, eight months after beginning the cannabis treatment, my MRI was reviewed by a leading Radiologist, my Neuro Oncologist, and my world renowned Brain Surgeon, and it was concluded that all that was remaining of the tumor regrowth was scar tissue. I will have another MRI in December. Because these tumors are chronic and tend to growback, I will always be living MRI to MRI, but the key word here is that I am living …and in great health with a great immune system.
None of this is to say trying CBD is off limits. “Cannabidiol is generally well-tolerated, which gives it a distinct advantage over other medications currently available for pain, including (and especially) opioids, non-steroidal anti-inflammatory drugs, steroids, anticonvulsant, and antidepressant medications,” says Seth Waldman, MD, anesthesiologist and director of the pain management division at the Hospital for Special Surgery. “I have seen a number of patients with difficult neuropathic pain syndromes who found it helpful.” (There’s also a study on this neuropathic pain—that burning-like sensation that affects the nervous system as Craft mentioned earlier. Research showed, though weak, it had a positive effect.)
Oral dronabinol (THC) is marketed in synthetic form as Marinol® (Solvay Pharmaceuticals) in various countries, and was approved in the USA for nausea associated with chemotherapy in 1985, and in 1992 for appetite stimulation in HIV/AIDS. Oral dronabinol’s expense, variability of action, and attendant intoxication and dysphoria have limited its adoption by clinicians (Calhoun et al 1998). Two open label studies in France of oral dronabinol for chronic neuropathic pain in 7 subjects (Clermont-Gnamien et al 2002) and 8 subjects (Attal et al 2004), respectively, failed to show significant benefit on pain or other parameters, and showed adverse event frequently requiring discontinuation with doses averaging 15–16.6 mg THC. Dronabinol did demonstrate positive results in a clinical trial of multiple sclerosis pain in two measures (Svendsen et al 2004), but negative results in post-operative pain (Buggy et al 2003) (Table 1). Another uncontrolled case report in three subjects noted relief of intractable pruritus associated with cholestatic jaundice employing oral dronabinol (Neff et al 2002). Some authors have noted patient preference for whole cannabis preparations over oral THC (Joy et al 1999), and the contribution of other components beyond THC to therapeutic benefits (McPartland and Russo 2001). Inhaled THC leads to peak plasma concentration within 3–10 minutes, followed by a rapid fall while levels of intoxication are still rising, and with systemic bioavailability of 10%–35% (Grotenhermen 2004). THC absorption orally is slow and erratic with peak serum levels in 45–120 minutes or longer. Systemic bioavailability is also quite low due to rapid hepatic metabolism on first pass to 11-hydroxy-THC. A rectal suppository of THC-hemisuccinate is under investigation (Broom et al 2001), as are transdermal delivery techniques (Challapalli and Stinchcomb 2002). The terminal half-life of THC is quite prolonged due to storage in body lipids (Grotenhermen 2004).

Currently, the U.S. National Library of Medicine lists just 25 clinical studies involving CBD and its effects on pain. Only a handful of those have been completed so far, but there are more in the works. Many of these trials involve pain in people with advanced cancer, and while some show positive pay-offs, others demonstrate that cannabis treatment doesn’t provide any more relief than a placebo. The catch: Most of this science involves both CBD and THC (or Δ9-tetrahydrocannabinol, the part of cannabis that does give you a high).


To get an idea of the benefits of CBD, just take a look at video of CBD oil helping with a form of childhood epilepsy called Dravet syndrome. The first use of CBD for Dravet’s syndrome was given to a patient who was having 300 seizures a week. I first talked about this video last year Is Weed Healthy? The Controversial Truth About The Science Of Marijuana…
I am not sure if anyone will be able to give you concrete advise online, as it depends on the state of your condition. Generally speaking the lower mg bottles probably won’t be as effective for arthritis, as they are more effective for anxiety and acute pain. When choosing an oil for any condition, it’s important to understand the state of your condition and your general health. It’s always best to speak to your primary doctor before you take any form of medication but if you do wish to try it, then start with a low dosage and work your way up – until you find what works for you. Hope that helps.
You are not getting enough CBD. You are only getting 1mg per dose which is only 2mg a day. Get a CBD oil from this list above. Find out what mg is per 1ml. Then calculate down to mg per 1 drop. I use one of the companies listed above. It has 50mg per 1ml and 1.6 mg per drop. Start out very low with a couple of drops under your tongue. Wait 2 hours and try a couple of drops again. Keep a log of how much and time you are taking it. I am up to 8 drops every 4 hours. Be patient and work your way up to your “sweet spot”. Believe me, you will know when you get your right dosage. This is my second try with a different company. It takes time and patience but hang in there.
"CBD increases the circulating levels of your natural endocannabinoids, which, in turn, interact with your cannabinoid receptors," Bonn-Miller says. "CBD has also been shown to interact with serotonin receptors, and that may be part of why it has some beneficial effects on anxiety. It also interacts with some pain receptors, which may be why we're starting to see effects on pain and inflammation."
Yet the DEA has stated unequivocally that it considers CBD to be illegal under the Controlled Substances Act. “CBD derived from the cannabis plant is controlled under Schedule I of the CSA because it is a naturally occurring constituent of marijuana,” Joseph Rannazzisi, the deputy assistant administrator of the DEA, told a congressional panel in June. “While there is ongoing research into a potential medical use of CBD, at this time, CBD has no currently accepted medical use in the USA.” Moreover, DEA spokesman Eduardo Chavez told the New Republic that Medical Marijuana, Inc.’s in-house opinion with regards to CBD has no merit. “The bottom line,” Chavez said, “is the oil is part of the marijuana plant, and the marijuana plant is currently a Schedule I controlled substance under federal law.”
I will be traveling soon (Vegas), and typically have an extremely hard time falling asleep, if I fall asleep at all, while traveling. In the past I have gone 3 days without sleep only to have to rely on ambien (seems to be the only thing that will knock me out). While at home it takes me a while to fall asleep but it’s not impossible. You mention you take 2-3 capsules to help you sleep, will this be sufficient enough to knock me out or would that require a higher dose? Or would a different product entirely, such as one with more THC be more effective? I recently came across an article on PubMed (not sure if it was mentioned above) that stated that CBD usually has the opposite effect on aiding sleep and that THC is better for sleep. However, you did mention higher dose CBD will not have the opposite effect. So I’m a bit confused.
It’s also one of the strongest and most concentrated CBD products on the market today. With a grain-of-rice-sized recommended serving taken orally twice a day, its potent punch acts quickly—in just ten to fifteen minutes—to provide powerful relief. Furthermore, it offers terrific value for your money, boasting more CBD per dollar than many other CBD products.
Thank you for your response. The oil I got was number 22 on the list. I chose that one because it was available at the grocery store where I shop, and was relatively inexpensive. As I’ve said, I’m new at this and trying to get some relief from back & neck pain. But… if I used my oil as often as you do (8 drops every 4 hours) I would use up a bottle in less that 2 days. Being retired and on a fixed income, that’s not feasible.
But Hague has something else he wants to show me. He leads me into a moist propagation room, where a young crop is taking root in near darkness. These babies, tagged with yellow labels, are being grown strictly for medical purposes. They’re all clones, cuttings from a mother plant. Hague is proud of this variety, which contains almost no THC but is rich in CBD and other compounds that have shown at least anecdotal promise in treating such diseases and disorders as multiple sclerosis, psoriasis, post-traumatic stress disorder, dementia, schizophrenia, osteoporosis, and amyotrophic lateral sclerosis (Lou Gehrig’s disease).
The degree to which cannabinoid analgesics will be adopted into adjunctive pain management practices currently remains to be determined. Data on Sativex use in Canada for the last reported 6-month period (January-July 2007) indicated that 81% of prescriptions issued for patients in that interval were refills (data on file, from Brogan Inc Rx Dynamics), thus indicating in some degree an acceptance of, and a desire to, continue such treatment. Given their multi-modality effects upon various nociceptive pathways, their adjunctive side benefits, the efficacy and safety profiles to date of specific preparations in advanced clinical trials, and the complementary mechanisms and advantages of their combination with opioid therapy, the future for cannabinoid therapeutics appears very bright, indeed.
Cannabidiol (CBD) oil is used by some people with chronic pain. CBD oil may reduce pain, inflammation, and overall discomfort related to a variety of health conditions. CBD oil is a product made from cannabis. It’s a type of cannabinoid, a chemical found naturally in marijuana and hemp plants. It doesn’t cause the “high” feeling often associated with cannabis, which is caused by a different type of cannabinoid called THC.

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